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ONLINE ISSN : 1347-5223
PRINT ISSN : 0009-2363
CHEMICAL & PHARMACEUTICAL BULLETIN
Vol. 49 (2001) , No. 4


Regular Articles

Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 1. Conversion of 5-Substituent on Oxazolidinone 347
Ryukou TOKUYAMA, Yoshiei TAKAHASHI, Yayoi TOMITA, Tomio SUZUKI, Toshihiko YOSHIDA, Nobuhiko IWASAKI, Noriyuki KADO, Eiichi OKEZAKI and Osamu NAGATA
Release Date: 2002/04/26
[Abstract] [PDF (71K)

Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 2.1) Relationship between Lipophilicity and Antibacterial Activity in 5-Thiocarbonyl Oxazolidinones 353
Ryukou TOKUYAMA, Yoshiei TAKAHASHI, Yayoi TOMITA, Masatoshi TSUBOUCHI, Toshihiko YOSHIDA, Nobuhiko IWASAKI, Noriyuki KADO, Eiichi OKEZAKI and Osamu NAGATA
Release Date: 2002/04/26
[Abstract] [PDF (88K)

Structure-Activity Relationship (SAR) Studies on Oxazolidinone Antibacterial Agents. 3.1) Synthesis and Evaluation of 5-Thiocarbamate Oxazolidinones 361
Ryukou TOKUYAMA, Yoshiei TAKAHASHI, Yayoi TOMITA, Masatoshi TSUBOUCHI, Nobuhiko IWASAKI, Noriyuki KADO, Eiichi OKEZAKI and Osamu NAGATA
Release Date: 2002/04/26
[Abstract] [PDF (72K)

Photochemical and Oxidative Degradation of the Solid-State Tretinoin Tocoferil 368
Reiko TERAOKA, Yasuyuki KONISHI and Yoshihisa MATSUDA
Release Date: 2002/04/26
[Abstract] [PDF (65K)

Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer 373
Tatsuya SUZUKI, Hiroshi KIKUCHI, Etsuo YONEMOCHI, Katsuhide TERADA and Keiji YAMAMOTO
Release Date: 2002/04/26
[Abstract] [PDF (70K)

Synthesis and Anti-influenza Virus Activity of Tricyclic Compounds with a Unique Amine Moiety 379
Mitsuru OKA, Yoshiro ISHIWATA, Noriyuki IWATA, Naoki HONDA and Takuji KAKIGAMI
Release Date: 2002/04/26
[Abstract] [PDF (66K)

Acid-Catalyzed Photoreaction of 6-Chloro-1, 3-Dimethyluracil and Mesitylene: Formation of Photocycloadducts and Their Characterization1) 384
Kazue OHKURA, Ken-ichi NISHIJIMA and Koh-ichi SEKI
Release Date: 2002/04/26
[Abstract] [PDF (92K)

Synthesis of New Fused Pyrimidines by Isocyanate and Isothiocyanate 391
A.Z.M. Shaifullah CHOWDHURY and Yasuyuki SHIBATA
Release Date: 2002/04/26
[Abstract] [PDF (71K)

Prolyl Endopeptidase Inhibitors from the Underground Part of Rhodiola sachalinensis 396
Wenzhe FAN, Yasuhiro TEZUKA, Khin May NI and Shigetoshi KADOTA
Release Date: 2002/04/26
[Abstract] [PDF (98K)

Reaction Kinetics of Solid-state Cyclization of Enalapril Maleate Investigated by Isothermal FT-IR Microscopic System 402
Shun-Li WANG, Shan-Yang LIN and Ting-Fang CHEN
Release Date: 2002/04/26
[Abstract] [PDF (76K)

Synthesis of Phenanthridones Using Diels—Alder Reactions of 4-Substituted 2(1H)-Quinolones Acting as Dienophiles 407
Reiko FUJITA, Kazuhiro WATANABE, Toshiteru YOSHISUJI, Hisao MATSUZAKI, Yoshihiro HARIGAYA and Hiroshi HONGO
Release Date: 2002/04/26
[Abstract] [PDF (85K)

Viewing of Complex Molecules of Ethidium Bromide and Plasmid DNA in Solution by Atomic Force Microscopy 413
Kuniharu UTSUNO, Masamichi TSUBOI, Shunji KATSUMATA and Toschitake IWAMOTO
Release Date: 2002/04/26
[Abstract] [PDF (167K)

The Molecular and Crystal Structure of tert-Butyl Nα-tert-Butoxycarbonyl-L-(S-trityl)cysteinate and the Conformation-Stabilizing Function of Weak Intermolecular Bonding 418
Anna Eugenia KOZIOL, Beata SZADY, Elzbieta MASIUKIEWICZ, Barbara RZESZOTARSKA and Malgorzata Anna BRODA
Release Date: 2002/04/26
[Abstract] [PDF (96K)

Synthesis and Gastrointestinal Prokinetic Activity of Novel Benzamide Derivatives with Amphoteric Side Chains 424
Jun SAKAGUCHI, Nobuhiko IWASAKI, Yuji IWANAGA, Takaharu SAITO, Eiji TAKAHARA, Hideo KATO and Miyoji HANAOKA
Release Date: 2002/04/26
[Abstract] [PDF (136K)

Studies on the Constituents of Cimicifuga Species. XXVIII.1) Four New Cycloart-7-enol Glycosides from the Underground Parts of Cimicifuga simplex WORMSK 437
Akiko KUSANO, Makio SHIBANO, Daisuke TSUKAMOTO and Genjiro KUSANO
Release Date: 2002/04/26
[Abstract] [PDF (73K)

Six New Dammarane-type Triterpene Saponins from the Leaves of Panax ginseng 442
De-Qiang DOU, Ying-Jie CHEN, Li-Hong LIANG, Fa-Gen PANG, Noriko SHIMIZU and Tadahiro TAKEDA
Release Date: 2002/04/26
[Abstract] [PDF (69K)

Constituents of Holothuroidea. 10.1) Isolation and Structure of a Biologically Active Ganglioside Molecular Species from the Sea Cucumber Holothuria leucospilota 447
Koji YAMADA, Rei MATSUBARA, Masafumi KANEKO, Tomofumi MIYAMOTO and Ryuichi HIGUCHI
Release Date: 2002/04/26
[Abstract] [PDF (80K)

Sweet Pregnane Glycosides from Telosma procumbens 453
Vo Duy HUAN, Kazuhiro OHTANI, Ryoji KASAI, Kazuo YAMASAKI and Nguyen Viet TUU
Release Date: 2002/04/26
[Abstract] [PDF (86K)

Convenient Synthesis of 4-Trifluoromethyl-Substituted Imidazole Derivatives 461
Masami KAWASE, Setsuo SAITO and Teruo KURIHARA
Release Date: 2002/04/26
[Abstract] [PDF (61K)

Analysis of the Marker Compounds of Rhodiola rosea L. (Golden Root) by Reversed Phase High Performance Liquid Chromatography 465
Markus GANZERA, Yurdanur YAYLA and Ikhlas A. KHAN
Release Date: 2002/04/26
[Abstract] [PDF (51K)

Stereoselective Reactions. XXXIV.1) Enantioselective Deprotonation of Prochiral 4-Substituted Cyclohexanones Using Chiral Bidentate Lithium Amides Having a Bulky Group Instead of a Phenyl Group on the Chiral Carbon 468
Masaharu TORIYAMA, Keizo SUGASAWA, Shigeyasu MOTOHASHI, Norio TOKUTAKE and Kenji KOGA
Release Date: 2002/04/26
[Abstract] [PDF (66K)


Notes

Ab Initio Molecular Orbital Study of Reactivity of Active Alkyl Groups. IV. Nitrosation of Acyclic Carbonyl Compound with Methyl Nitrite via “Open-Chain” Transition State 473
Tokihiro NIIYA, Hirohito IKEDA, Miho YUKAWA and Yoshinobu GOTO
Release Date: 2002/04/26
[Abstract] [PDF (60K)

Practical Synthesis of a 1β-Methylcarbapenem, J-111, 225, Using 4-Mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a Precursor 476
Hideaki IMAMURA, Aya SHIMIZU, Hiroki SATO, Yuichi SUGIMOTO, Shunji SAKURABA, Koji YAMADA and Hajime MORISHIMA
Release Date: 2002/04/26
[Abstract] [PDF (60K)

Synthesis of 2-Substituted Trifluoromethylquinolines for the Evaluation of Leishmanicidal Activity 480
Joël DADE, Olivier PROVOT, Henri MOSKOWITZ, Joëlle MAYRARGUE and Eric PRINA
Release Date: 2002/04/26
[Abstract] [PDF (59K)

A Novel Antivirally Active Fucan Sulfate Derived from an Edible Brown Alga, Sargassum horneri 484
Srisomporn PREEPRAME, Kyoko HAYASHI, Jung-Bum LEE, Ushio SANKAWA and Toshimitsu HAYASHI
Release Date: 2002/04/26
[Abstract] [PDF (38K)

Revised Structure of Cercidinin A, a Novel Ellagitannin Having (R)-Hexahydroxydiphenoyl Esters at the 3, 4-Positions of Glucopyranose 486
Takashi TANAKA, Gen-ichiro NONAKA, Makoto ISHIMATSU, Itsuo NISHIOKA and Isao KOUNO
Release Date: 2002/04/26
[Abstract] [PDF (44K)

Amino Acids and Peptides. XXXVIII. Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol) Hybrids by the Solid Phase Method 488
Mitsuko MAEDA, Haruhiko KAMADA, Keiko HOJO, Yoko YAMAMOTO, Shinsaku NAKAGAWA, Timothy J. SMITH, Tadanori MAYUMI and Koichi KAWASAKI
Release Date: 2002/04/26
[Abstract] [PDF (70K)

Studies on the Constituents of Broussonetia Species VIII. Four New Pyrrolidine Alkaloids, Broussonetines R, S, T, and V and a New Pyrroline Alkaloid, Broussonetine U, from Broussonetia kazinoki SIEB. 492
Daisuke TSUKAMOTO, Makio SHIBANO, Rieko OKAMOTO and Genjiro KUSANO
Release Date: 2002/04/26
[Abstract] [PDF (76K)

Cycloaddition of 2(1H)-Pyridones Having a Methoxycarbonyl Group to 1, 3-Butadiene Derivatives 497
Reiko FUJITA, Masato HOSHINO, Hiroshi TOMISAWA, Hisao MATSUZAKI and Hiroshi HONGO
Release Date: 2002/04/26
[Abstract] [PDF (67K)


Communications to the Editor

Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure 501
Masayuki EBISAWA, Kiminori OHTA, Emiko KAWACHI, Hiroshi FUKASAWA, Yuichi HASHIMOTO and Hiroyuki KAGECHIKA
Release Date: 2002/04/26
[Abstract] [PDF (50K)

The Biosynthesis of Broussonetines: Origin of the Carbon Skeleton 504
Makio SHIBANO, Daisuke TSUKAMOTO, Takae INOUE, Yoko TAKASE and Genjiro KUSANO
Release Date: 2002/04/26
[Abstract] [PDF (53K)

The First Example for Cycloenantiomeric Hexahomooxacalix[3]arenes 507
Kazunori TSUBAKI, Tadamune OTSUBO, Takayoshi KINOSHITA, Mitsuru KAWADA and Kaoru FUJI
Release Date: 2002/04/26
[Abstract] [PDF (64K)



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